Researchers demonstrated that Rac1 is overactive in the airways of patients with severe asthma and is essential for airway smooth muscle cell proliferation.
[Thorax]
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in%20SMC%20or%20pharmacological%20inhibition%20of%20Rac1%20by%20nebulisation%20of%20NSC23766%20prevented%20AHR%20and%20aSMC%20hyperplasia%20in%20a%20mouse%20model%20of%20severe%20asthma.%20Moreover%2C%20the%20Rac1%20inhibitor%20prevented%20goblet%20cell%20hyperplasia%20and%20epithelial%20cell%20hypertrophy%20whereas%20treatment%20with%20corticosteroids%20had%20less%20effect.%20Nebulisation%20of%20NSC23766%20also%20decreased%20eosinophil%20accumulation%20in%20the%20bronchoalveolar%20lavage%20of%20asthmatic%20mice.%5CnConclusion%20This%20study%20demonstrates%20that%20Rac1%20is%20overactive%20in%20the%20airways%20of%20patients%20with%20severe%20asthma%20and%20is%20essential%20for%20aSMC%20proliferation.%20It%20also%20provides%20evidence%20that%20Rac1%20is%20causally%20involved%20in%20AHR%20and%20airway%20remodelling.%20Rac1%20may%20represent%20as%20an%20interesting%20target%20for%20treating%20both%20AHR%20and%20airway%20remodelling%20of%20patients%20with%20severe%20asthma.%22%2C%22date%22%3A%222021%5C%2F02%5C%2F04%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1136%5C%2Fthoraxjnl-2020-216271%22%2C%22ISSN%22%3A%220040-6376%2C%201468-3296%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fthorax.bmj.com%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F02%5C%2F04%5C%2Fthoraxjnl-2020-216271%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-05T18%3A32%3A33Z%22%7D%7D%5D%7D
Dilasser, F., Rose, L., Hassoun, D., Klein, M., Rousselle, M., Brosseau, C., Guignabert, C., Taillé, C., Dombret, M. C., Candia, L. D., Heddebaut, N., Bouchaud, G., Pretolani, M., Magnan, A., Loirand, G., & Sauzeau, V. (2021). Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling. Thorax. https://doi.org/10.1136/thoraxjnl-2020-216271 Cite
