Researchers showed that during pregnancy, administration of a diet rich in the aryl hydrocarbon receptor (AHR) ligand indole-3-carbinole, or of breast milk, activates AHR and prevents necrotizing enterocolitis in newborn mice by reducing Toll-like receptor 4 signaling in the newborn gut.
[Nature Communications]
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Lu, P., Yamaguchi, Y., Fulton, W. B., Wang, S., Zhou, Q., Jia, H., Kovler, M. L., Salazar, A. G., Sampah, M., Prindle, T., Wipf, P., Sodhi, C. P., & Hackam, D. J. (2021). Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis. Nature Communications, 12(1), 1042. https://doi.org/10.1038/s41467-021-21356-4 Cite
