In colitis crypts, a notable cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and the ligand EDA-A2, suppressed colonic stemness and epithelial repair by inhibiting β-catenin/c-Myc. In differentiated intestinal epithelial cells, miR-494-3p inhibited macrophage recruitment, M1 activation and EDA-A2 secretion by targeting IKKβ/NF-κB in colitis.
[Communications Biology]
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Song, L., Chang, R., Sun, X., Lu, L., Gao, H., Lu, H., Lin, R., Xu, X., Liu, Z., & Zhan, L. (2021). Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-021-01730-0 Cite
