Investigators showed induced Notch2IC-expression in follicular B (FoB) cells re-programs mature FoB cells into bona fide marginal zone B cells as was evident from the surface phenotype, localization, immunological function and transcriptome of these cells.
[Nature Communications]
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Lechner, M., Engleitner, T., Babushku, T., Schmidt-Supprian, M., Rad, R., Strobl, L. J., & Zimber-Strobl, U. (2021). Notch2-mediated plasticity between marginal zone and follicular B cells. Nature Communications, 12(1), 1111. https://doi.org/10.1038/s41467-021-21359-1 Cite
