Home Newsletters Organoid News MAP3K2-Regulated Intestinal Stromal Cells Define a Distinct Stem Cell Niche

MAP3K2-Regulated Intestinal Stromal Cells Define a Distinct Stem Cell Niche

0
To determine the physiological role of MAP3K2-regulated intestinal stromal cells (MRISCs), scientists co-cultured MRISCs with colonic organoids and found that organoid growth was greater than when co-cultured with MRISC-depleted stromal cells
[Nature]
6445218 {6445218:PKRTRQTZ} apa 50 1 159695 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-fa7c48f28a99c2a8e346bd1c3a804abf%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22PKRTRQTZ%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wu%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWu%2C%20N.%2C%20Sun%2C%20H.%2C%20Zhao%2C%20X.%2C%20Zhang%2C%20Y.%2C%20Tan%2C%20J.%2C%20Qi%2C%20Y.%2C%20Wang%2C%20Q.%2C%20Ng%2C%20M.%2C%20Liu%2C%20Z.%2C%20He%2C%20L.%2C%20Niu%2C%20X.%2C%20Chen%2C%20L.%2C%20Liu%2C%20Z.%2C%20Li%2C%20H.-B.%2C%20Zeng%2C%20Y.%20A.%2C%20Roulis%2C%20M.%2C%20Liu%2C%20D.%2C%20Cheng%2C%20J.%2C%20Zhou%2C%20B.%2C%20%26%23x2026%3B%20Su%2C%20B.%20%282021%29.%20MAP3K2-regulated%20intestinal%20stromal%20cells%20define%20a%20distinct%20stem%20cell%20niche.%20%3Ci%3ENature%3C%5C%2Fi%3E%2C%201%26%23x2013%3B5.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-021-03283-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-021-03283-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DPKRTRQTZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MAP3K2-regulated%20intestinal%20stromal%20cells%20define%20a%20distinct%20stem%20cell%20niche%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ningbo%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongxiang%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyun%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yao%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jianmei%22%2C%22lastName%22%3A%22Tan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuanyuan%22%2C%22lastName%22%3A%22Qi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qun%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Ng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhaoyuan%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lingjuan%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyin%22%2C%22lastName%22%3A%22Niu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhiduo%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hua-Bing%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%20Arial%22%2C%22lastName%22%3A%22Zeng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manolis%22%2C%22lastName%22%3A%22Roulis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dou%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinke%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lai%20Guan%22%2C%22lastName%22%3A%22Ng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Duowu%22%2C%22lastName%22%3A%22Zou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Youqiong%22%2C%22lastName%22%3A%22Ye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20A.%22%2C%22lastName%22%3A%22Flavell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florent%22%2C%22lastName%22%3A%22Ginhoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bing%22%2C%22lastName%22%3A%22Su%22%7D%5D%2C%22abstractNote%22%3A%22Intestinal%20stromal%20cells%20are%20known%20to%20modulate%20the%20propagation%20and%20differentiation%20of%20intestinal%20stem%20cells1%2C2.%20However%2C%20the%20precise%20cellular%20and%20molecular%20mechanisms%20by%20which%20this%20diverse%20stromal%20cell%20population%20maintains%20tissue%20homeostasis%20and%20repair%20are%20poorly%20understood.%20Here%20we%20describe%20a%20subset%20of%20intestinal%20stromal%20cells%2C%20named%20MAP3K2-regulated%20intestinal%20stromal%20cells%20%28MRISCs%29%2C%20and%20show%20that%20they%20are%20the%20primary%20cellular%20source%20of%20the%20WNT%20agonist%20R-spondin%201%20following%20intestinal%20injury%20in%20mice.%20MRISCs%2C%20which%20are%20epigenetically%20and%20transcriptomically%20distinct%20from%20subsets%20of%20intestinal%20stromal%20cells%20that%20have%5Cu00a0previously%20been%20reported3%5Cu20136%2C%20are%20strategically%20localized%20at%20the%20bases%20of%20colon%20crypts%2C%20and%20function%20to%20maintain%20LGR5%2B%20intestinal%20stem%20cells%20and%20protect%20against%20acute%20intestinal%20damage%20through%20enhanced%20R-spondin%201%20production.%20Mechanistically%2C%20this%20MAP3K2%20specific%20function%20is%20mediated%20by%20a%20previously%20unknown%20reactive%20oxygen%20species%20%28ROS%29%5Cu2013MAP3K2%5Cu2013ERK5%5Cu2013KLF2%20axis%20to%20enhance%20production%20of%20R-spondin%201.%20Our%20results%20identify%20MRISCs%20as%20a%20key%20component%20of%20an%20intestinal%20stem%20cell%20niche%20that%20specifically%20depends%20on%20MAP3K2%20to%20augment%20WNT%20signalling%20for%20the%20regeneration%20of%20damaged%20intestine.%22%2C%22date%22%3A%222021-03-03%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-021-03283-y%22%2C%22ISSN%22%3A%221476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-021-03283-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-03T20%3A21%3A41Z%22%7D%7D%5D%7D
Wu, N., Sun, H., Zhao, X., Zhang, Y., Tan, J., Qi, Y., Wang, Q., Ng, M., Liu, Z., He, L., Niu, X., Chen, L., Liu, Z., Li, H.-B., Zeng, Y. A., Roulis, M., Liu, D., Cheng, J., Zhou, B., … Su, B. (2021). MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 1–5. https://doi.org/10.1038/s41586-021-03283-y Cite
Abstract
Exit mobile version