Investigators characterized patients with AML with plasmacytoid dendritic cells (pDC) expansion, which they observed in ∼5% of AML cases. pDC-AMLs often possessed cross-lineage antigen expression and have adverse risk stratification with poor outcome.
[Blood]
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Xiao, W., Chan, A., Waarts, M. R., Mishra, T., Liu, Y., Cai, S. F., Yao, J., Gao, Q., Bowman, R. L., Koche, R. P., Csete, I. S., DelGaudio, N. L., Derkach, A., Baik, J., Yanis, S., Famulare, C. A., Patel, M., Arcila, M. E., Stahl, M., … Levine, R. L. (2021). Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia. Blood, 137(10), 1377–1391. https://doi.org/10.1182/blood.2020007897 Cite
