Mechanistically, pigment epithelium-derived factor (PEDF) inhibited the proliferation, migration, and tube formation of lymphatic endothelial cells and promotes cell apoptosis.
[Cell Death & Disease]
6445212
{6445212:K4FJE56I}
apa
50
1
160199
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-619936d4acaae54da4c2bdbacfec77f5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K4FJE56I%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Luo%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELuo%2C%20C.%2C%20Yin%2C%20H.%2C%20Gao%2C%20T.%2C%20Ma%2C%20C.%2C%20Liu%2C%20J.%2C%20Zhang%2C%20T.%2C%20Xu%2C%20Z.%2C%20Wang%2C%20X.%2C%20Zhang%2C%20D.%2C%20Qi%2C%20W.%2C%20Yang%2C%20Z.%2C%20Gao%2C%20G.%2C%20Yang%2C%20X.%2C%20%26amp%3B%20Zhou%2C%20T.%20%282021%29.%20PEDF%20inhibits%20lymphatic%20metastasis%20of%20nasopharyngeal%20carcinoma%20as%20a%20new%20lymphangiogenesis%20inhibitor.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%284%29%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03583-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03583-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DK4FJE56I%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22PEDF%20inhibits%20lymphatic%20metastasis%20of%20nasopharyngeal%20carcinoma%20as%20a%20new%20lymphangiogenesis%20inhibitor%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chuanghua%22%2C%22lastName%22%3A%22Luo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haofan%22%2C%22lastName%22%3A%22Yin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tianxiao%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caiqi%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junxi%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ting%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zumin%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Danrui%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weiwei%22%2C%22lastName%22%3A%22Qi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhonghan%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guoquan%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xia%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ti%22%2C%22lastName%22%3A%22Zhou%22%7D%5D%2C%22abstractNote%22%3A%22Nasopharyngeal%20carcinoma%20%28NPC%29%20is%20one%20of%20the%20most%20malignant%20tumors%20in%20southern%20China%20and%20Asia%2C%20and%20lymph%20node%20metastasis%20is%20an%20important%20cause%20for%20treatment%20failure.%20Lymphangiogenesis%20is%20a%20crucial%20step%20in%20lymphatic%20metastasis%20of%20NPC%2C%20while%20little%20is%20known%20about%20lymphangiogenesis%20in%20NPC.%20Similar%20to%20angiogenesis%2C%20lymphangitic%20neovascularization%20is%20a%20process%20of%20balance%20between%20pro-lymphangiogenesis%20and%20anti-lymphangiogenesis%20factors%2C%20but%20there%20are%20few%20studies%20on%20endogenous%20lymphangiogenesis%20inhibitors.%20Pigment%20epithelium-derived%20factor%20%28PEDF%29%20is%20a%20well-known%20effective%20endogenous%20angiogenesis%20inhibitor.%20However%2C%20the%20relationship%20between%20PEDF%20and%20lymphangiogenesis%20remains%20unknown.%20Our%20present%20study%20reveals%20that%20PEDF%20is%20lowly%20expressed%20in%20human%20NPC%20tissues%20with%20poor%20prognosis%20and%20is%20negatively%20correlated%20with%20lymphatic%20vessel%20density%20%28LVD%29.%20Consistently%2C%20PEDF%20inhibits%20lymphangiogenesis%20and%20lymphatic%20metastasis%20of%20NPC%20in%20vivo%20experiments.%20Mechanistically%2C%20PEDF%20inhibits%20the%20proliferation%2C%20migration%2C%20and%20tube%20formation%20of%20lymphatic%20endothelial%20cells%20and%20promotes%20cell%20apoptosis.%20On%20the%20other%20hand%2C%20PEDF%20reduces%20the%20expression%20and%20secretion%20of%20vascular%20endothelial%20growth%20factor%20C%20%28VEGF-C%29%20of%20NPC%20cells%20through%20the%20nuclear%20factor-%5Cu03baB%20%28NF-%5Cu03baB%29%20signaling%20pathway.%20Our%20findings%20indicate%20that%20PEDF%20plays%20a%20vital%20role%20in%20lymphatic%20metastasis%20by%20targeting%20both%20lymphatic%20endothelial%20cells%20and%20NPC%20cells%2C%20and%20PEDF%20may%20represent%20a%20novel%20therapeutic%20target%20for%20NPC.%22%2C%22date%22%3A%222021-03-17%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03583-1%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03583-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-17T16%3A51%3A25Z%22%7D%7D%5D%7D
Luo, C., Yin, H., Gao, T., Ma, C., Liu, J., Zhang, T., Xu, Z., Wang, X., Zhang, D., Qi, W., Yang, Z., Gao, G., Yang, X., & Zhou, T. (2021). PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03583-1 Cite
