Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
[Nature Communications]
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Zhang, B., Li, Y., Wu, Q., Xie, L., Barwick, B., Fu, C., Li, X., Wu, D., Xia, S., Chen, J., Qian, W. P., Yang, L., Osunkoya, A. O., Boise, L., Vertino, P. M., Zhao, Y., Li, M., Chen, H.-R., Kowalski, J., … Dong, J.-T. (2021). Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nature Communications, 12(1), 1714. https://doi.org/10.1038/s41467-021-21976-w Cite
