Researchers hypothesized that a single administration of an adeno‐associated virus coding for an anti‐eosinophil monoclonal antibody that induces eosinophil clearance would treat on a persistent basis a murine model of eosinophilic esophagitis.
[Allergy]
1254621
{1254621:9RR3WSS4}
apa
50
1
160340
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-8743da9d3758eef0615a08f7114ade2a%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229RR3WSS4%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Camilleri%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECamilleri%2C%20A.%20E.%2C%20Nag%2C%20S.%2C%20Russo%2C%20A.%20R.%2C%20Stiles%2C%20K.%20M.%2C%20Crystal%2C%20R.%20G.%2C%20%26amp%3B%20Pagovich%2C%20O.%20E.%20%28n.d.%29.%20Gene%20Therapy%20for%20a%20Murine%20Model%20of%20Eosinophilic%20Esophagitis.%20%3Ci%3EAllergy%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fall.14822%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fall.14822%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3D9RR3WSS4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Gene%20Therapy%20for%20a%20Murine%20Model%20of%20Eosinophilic%20Esophagitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20E.%22%2C%22lastName%22%3A%22Camilleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saparja%22%2C%22lastName%22%3A%22Nag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20R.%22%2C%22lastName%22%3A%22Russo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katie%20M.%22%2C%22lastName%22%3A%22Stiles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%20G.%22%2C%22lastName%22%3A%22Crystal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odelya%20E.%22%2C%22lastName%22%3A%22Pagovich%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Eosinophils%20are%20specialized%20granulocytic%20effector%20cells%20that%20store%20and%20release%20highly%20active%20mediators%20used%20in%20immune%20defense.%20Eosinophils%20are%20also%20implicated%20in%20the%20pathogenesis%20of%20allergic%20disorders%2C%20including%20eosinophilic%20esophagitis%20%28EoE%29%2C%20a%20chronic%20disorder%20characterized%20by%20infiltration%20of%20eosinophils%20into%20the%20esophagus%20and%20release%20of%20mediators%20that%20damage%20tissue%2C%20resulting%20in%20gastrointestinal%20morbidity%2C%20food%20impaction%20and%20dysphagia.%20Treatment%20with%20elimination%20diets%20and%5C%2For%20topical%20corticosteroid%20therapy%20slow%20disease%20progression%2C%20but%20are%20complicated%20by%20adverse%20effects%2C%20limited%20compliance%20and%20loss%20of%20response%20to%20therapy.%20We%20hypothesized%20that%20a%20single%20administration%20of%20an%20adeno-associated%20virus%20%28AAV%29%20coding%20for%20an%20anti-eosinophil%20monoclonal%20antibody%20that%20induces%20eosinophil%20clearance%20%28anti-Siglec-F%29%20would%20treat%20on%20a%20persistent%20basis%20a%20murine%20model%20of%20EoE.%20Methods%20Amouse%20model%20of%20peanut-inducedEoE%20that%20mimics%20the%20human%20disease%20was%20established%20by%20sensitization%20and%20challenge%20with%20peanut%20extract.After%20challenge%2C%20these%20mice%20exhibited%20an%20EoE%20phenotype%20demonstrated%20byelevated%20levels%20of%20blood%20eosinophils%2C%20infiltration%20of%20eosinophils%20in%20the%20esophagus%20with%20associated%20esophageal%20remodelingand%20food%20impaction.%20Results%20The%20mice%20were%20treated%20with%20a%20single%20intravenous%20administration%20%281011%20genome%20copies%29%20of%20AAVrh.10mAnti-Eos%2C%20a%20serotype%20rh.10%20AAV%20vector%20coding%20for%20an%20anti-Siglec-F%20monoclonal%20antibody.%20Vector%20administration%20resulted%20in%20persistent%2C%20high%20levels%20of%20anti-Siglec-F%20antibody%20expression.%20Administration%20of%20AAVrh.10mAnti-Eos%20to%20the%20mouse%20model%20of%20EoEreduced%20blood%20%28p%3C0.02%29%20and%20esophageal%20eosinophil%20numbers%20%28p%3C0.002%29%2C%20protected%20from%20esophageal%20tissue%20remodeling%2C%20andminimized%20food%20impaction.%20Conclusion%20These%20results%20suggest%20that%20a%20single%20treatment%20with%20AAVrh.10mAnti-Eos%20has%20the%20potential%20to%20provide%20persistent%20therapeutic%20benefit%20to%20patients%20with%20EoE.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fall.14822%22%2C%22ISSN%22%3A%221398-9995%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpericles.pericles-prod.literatumonline.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fall.14822%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-22T18%3A18%3A21Z%22%7D%7D%5D%7D
Camilleri, A. E., Nag, S., Russo, A. R., Stiles, K. M., Crystal, R. G., & Pagovich, O. E. (n.d.). Gene Therapy for a Murine Model of Eosinophilic Esophagitis. Allergy, n/a(n/a). https://doi.org/https://doi.org/10.1111/all.14822 Cite
