Scientists identified non-neuroendocrine SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling.
[Nature Communications]
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Bebber, C. M., Thomas, E. S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M. N., Stüker, L., de Pádua Alves, C., Khonsari, A., Dammert, M. A., Parmaksiz, F., Tumbrink, H. L., Beleggia, F., Sos, M. L., Riemer, J., George, J., Brodesser, S., Thomas, R. K., … von Karstedt, S. (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications, 12(1), 2048. https://doi.org/10.1038/s41467-021-22336-4 Cite
