To characterize glycosylphosphatidylinositol-anchored protein-deficient and HLA-class I allele-lacking hematopoietic stem progenitor cells in acquired aplastic anemia (AA), researchers studied the peripheral blood of 56 AA patients in remission.
[Leukemia]
6445218
{6445218:MBIP66ZS}
apa
50
1
160889
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-01fbd7b5dd627132a4855a9a521692b4%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22MBIP66ZS%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yoroidaka%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYoroidaka%2C%20T.%2C%20Hosokawa%2C%20K.%2C%20Imi%2C%20T.%2C%20Mizumaki%2C%20H.%2C%20Katagiri%2C%20T.%2C%20Ishiyama%2C%20K.%2C%20Yamazaki%2C%20H.%2C%20Azuma%2C%20F.%2C%20Nanya%2C%20Y.%2C%20Ogawa%2C%20S.%2C%20%26amp%3B%20Nakao%2C%20S.%20%282021%29.%20Hematopoietic%20stem%20progenitor%20cells%20lacking%20HLA%20differ%20from%20those%20lacking%20GPI-anchored%20proteins%20in%20the%20hierarchical%20stage%20and%20sensitivity%20to%20immune%20attack%20in%20patients%20with%20acquired%20aplastic%20anemia.%20%3Ci%3ELeukemia%3C%5C%2Fi%3E%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41375-021-01202-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41375-021-01202-8%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DMBIP66ZS%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hematopoietic%20stem%20progenitor%20cells%20lacking%20HLA%20differ%20from%20those%20lacking%20GPI-anchored%20proteins%20in%20the%20hierarchical%20stage%20and%20sensitivity%20to%20immune%20attack%20in%20patients%20with%20acquired%20aplastic%20anemia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Takeshi%22%2C%22lastName%22%3A%22Yoroidaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kohei%22%2C%22lastName%22%3A%22Hosokawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tatsuya%22%2C%22lastName%22%3A%22Imi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroki%22%2C%22lastName%22%3A%22Mizumaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Takamasa%22%2C%22lastName%22%3A%22Katagiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ken%22%2C%22lastName%22%3A%22Ishiyama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hirohito%22%2C%22lastName%22%3A%22Yamazaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fumihiro%22%2C%22lastName%22%3A%22Azuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuhito%22%2C%22lastName%22%3A%22Nanya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seishi%22%2C%22lastName%22%3A%22Ogawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shinji%22%2C%22lastName%22%3A%22Nakao%22%7D%5D%2C%22abstractNote%22%3A%22To%20characterize%20glycosylphosphatidylinositol-anchored%20protein-deficient%20%28GPI%5B%5Cu2212%5D%29%20and%20HLA-class%20I%20allele-lacking%20%28HLA%5B%5Cu2212%5D%29%20hematopoietic%20stem%20progenitor%20cells%20%28HSPCs%29%20in%20acquired%20aplastic%20anemia%20%28AA%29%2C%20we%20studied%20the%20peripheral%20blood%20%28PB%29%20of%2056%20AA%20patients%20in%20remission%20who%20possessed%20both%20%28n%5Cu2009%3D%5Cu200913%2C%20Group%20A%29%20or%20either%20GPI%28%5Cu2212%29%20%28n%5Cu2009%3D%5Cu200934%2C%20Group%20B%29%20and%20HLA%28%5Cu2212%29%20%28n%5Cu2009%3D%5Cu20099%2C%20Group%20C%29%20cell%20populations.%20Seventy-seven%20percent%20%2810%5C%2F13%29%20of%20Group%20A%20had%20HLA%28%5Cu2212%29%20cells%20in%20all%20lineages%20of%20PB%20cells%2C%20including%20platelets%2C%20while%20only%2023%25%20%283%5C%2F13%29%20had%20GPI%28%5Cu2212%29%20cells%20in%20all%20lineages%2C%20and%20the%20median%20percentage%20of%20HLA%28%5Cu2212%29%20granulocytes%20in%20the%20total%20granulocytes%20%2821.2%25%29%20was%20significantly%20higher%20than%20that%20of%20GPI%28%5Cu2212%29%20granulocytes%20%280.28%25%2C%20P%5Cu2009%3C%5Cu20090.05%29.%20The%20greater%20lineage%20diversity%20in%20HLA%28%5Cu2212%29%20cells%20than%20in%20GPI%28%5Cu2212%29%20cells%20was%20also%20seen%20when%20Group%20B%20and%20Group%20C%20were%20compared.%20Longitudinal%20studies%20of%20seven%20patients%20in%20Group%20A%20showed%20a%20gradual%20decrease%20in%20the%20percentage%20of%20HLA%28%5Cu2212%29%20granulocytes%2C%20with%20a%20reciprocal%20increase%20in%20the%20GPI%28%5Cu2212%29%20granulocytes%20in%20four%20patients%20responding%20to%20cyclosporine%20%28CsA%29%20and%20an%20increase%20in%20the%20HLA%28%5Cu2212%29%20granulocytes%20with%20a%20stable%20or%20declining%20GPI%28%5Cu2212%29%20granulocytes%20in%20three%20patients%20in%20sustained%20remission%20off%20CsA%20therapy.%20These%20findings%20suggest%20that%20HLA%28%5Cu2212%29%20HSPCs%20differ%20from%20GPI%28%5Cu2212%29%20HSPCs%20in%20the%20hierarchical%20stage%20and%20sensitivity%20to%20immune%20attack%20in%20AA.%22%2C%22date%22%3A%222021-04-06%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41375-021-01202-8%22%2C%22ISSN%22%3A%221476-5551%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41375-021-01202-8%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-06T19%3A03%3A33Z%22%7D%7D%5D%7D
Yoroidaka, T., Hosokawa, K., Imi, T., Mizumaki, H., Katagiri, T., Ishiyama, K., Yamazaki, H., Azuma, F., Nanya, Y., Ogawa, S., & Nakao, S. (2021). Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia. Leukemia, 1–11. https://doi.org/10.1038/s41375-021-01202-8 Cite
