Home Newsletters Endothelial Cell News TRIM27 Contributes to Glomerular Endothelial Cell Injury in Lupus Nephritis by Mediating...

TRIM27 Contributes to Glomerular Endothelial Cell Injury in Lupus Nephritis by Mediating the FoxO1 Signaling Pathway

0
Researchers detected the expression of the tripartite motif-containing 27 (TRIM27) protein in glomerular endothelial cells in vivo and in vitro.
[Laboratory Investigation]
6445212 {6445212:B2TDUS79} apa 50 1 161154 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-9d25df87433a9ecb520650d7463d7652%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22B2TDUS79%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-14%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20J.%2C%20Xu%2C%20J.%2C%20Huang%2C%20J.%2C%20Gu%2C%20C.%2C%20Liu%2C%20Q.%2C%20Zhang%2C%20W.%2C%20Gao%2C%20F.%2C%20Tian%2C%20Y.%2C%20Miao%2C%20X.%2C%20Zhu%2C%20Z.%2C%20Jia%2C%20B.%2C%20Tian%2C%20Y.%2C%20Wu%2C%20L.%2C%20Zhao%2C%20H.%2C%20Feng%2C%20X.%2C%20%26amp%3B%20Liu%2C%20S.%20%282021%29.%20TRIM27%20contributes%20to%20glomerular%20endothelial%20cell%20injury%20in%20lupus%20nephritis%20by%20mediating%20the%20FoxO1%20signaling%20pathway.%20%3Ci%3ELaboratory%20Investigation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B15.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00591-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00591-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DB2TDUS79%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22TRIM27%20contributes%20to%20glomerular%20endothelial%20cell%20injury%20in%20lupus%20nephritis%20by%20mediating%20the%20FoxO1%20signaling%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinxi%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cunyang%22%2C%22lastName%22%3A%22Gu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qingjuan%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fan%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuexin%22%2C%22lastName%22%3A%22Tian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xinyan%22%2C%22lastName%22%3A%22Miao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zixuan%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baiyun%22%2C%22lastName%22%3A%22Jia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu%22%2C%22lastName%22%3A%22Tian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lunbi%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hang%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaojuan%22%2C%22lastName%22%3A%22Feng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuxia%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22Tripartite%20motif-containing%2027%20%28TRIM27%29%20belongs%20to%20the%20triple%20motif%20%28TRIM%29%20protein%20family%2C%20which%20plays%20a%20role%20in%20a%20variety%20of%20biological%20activities.%20Our%20previous%20study%20showed%20that%20the%20TRIM27%20protein%20was%20highly%20expressed%20in%20the%20glomerular%20endothelial%20cells%20of%20patients%20suffering%20from%20lupus%20nephritis%20%28LN%29.%20However%2C%20whether%20TRIM27%20is%20involved%20in%20the%20injury%20of%20glomerular%20endothelial%20cells%20in%20lupus%20nephritis%20remains%20to%20be%20clarified.%20Here%2C%20we%20detected%20the%20expression%20of%20the%20TRIM27%20protein%20in%20glomerular%20endothelial%20cells%20in%20vivo%20and%20in%20vitro.%20In%20addition%2C%20the%20influence%20of%20TRIM27%20knockdown%20on%20endothelial%20cell%20damage%20in%20MRL%5C%2Flpr%20mice%20and%20cultured%20human%20renal%20glomerular%20endothelial%20cells%20%28HRGECs%29%20was%20explored.%20The%20results%20revealed%20that%20the%20expression%20of%20TRIM27%20in%20endothelial%20cells%20was%20significantly%20enhanced%20in%20vivo%20and%20in%20vitro.%20Downregulating%20the%20expression%20of%20TRIM27%20inhibited%20the%20breakdown%20of%20the%20glycocalyx%20and%20the%20injury%20of%20endothelial%20cells%20via%20the%20FoxO1%20pathway.%20Moreover%2C%20HRGECs%20transfected%20with%20the%20WT-FoxO1%20plasmid%20showed%20a%20reduction%20in%20impairment%20caused%20by%20LN%20plasma.%20Furthermore%2C%20suppression%20of%20the%20protein%20kinase%20B%20%28Akt%29%20pathway%20could%20attenuate%20damage%20by%20mediating%20the%20expression%20of%20TRIM27.%20Thus%2C%20the%20present%20study%20showed%20that%20TRIM27%20participated%20in%20the%20injury%20of%20glomerular%20endothelial%20cells%20and%20served%20as%20a%20potential%20therapeutic%20target%20for%20the%20treatment%20of%20lupus%20nephritis.%22%2C%22date%22%3A%222021-04-14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41374-021-00591-9%22%2C%22ISSN%22%3A%221530-0307%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41374-021-00591-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-14T16%3A40%3A40Z%22%7D%7D%5D%7D
Liu, J., Xu, J., Huang, J., Gu, C., Liu, Q., Zhang, W., Gao, F., Tian, Y., Miao, X., Zhu, Z., Jia, B., Tian, Y., Wu, L., Zhao, H., Feng, X., & Liu, S. (2021). TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway. Laboratory Investigation, 1–15. https://doi.org/10.1038/s41374-021-00591-9 Cite
Full Article
Exit mobile version