Through a series of studies spanning in vitro efferocytosis, ex vivo intestinal organoids, and in vivo Cre-mediated deletion of Paneth cells, researchers showed that Paneth cells mediate apoptotic cell uptake of dying neighbors.
[Current Biology]
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Ventayol, P. S., Geiser, P., Martino, M. L. D., Florbrant, A., Fattinger, S. A., Walder, N., Sima, E., Shao, F., Gekara, N. O., Sundbom, M., Hardt, W.-D., Webb, D.-L., Hellström, P. M., Eriksson, J., & Sellin, M. E. (2021). Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2013963118 Cite
