Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
[Biochemical Pharmacology]
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Kim, T. J., Lee, H. J., Pyun, D. H., Abd El-Aty, A. M., Jeong, J. H., & Jung, T. W. (2021). Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress. Biochemical Pharmacology, 188, 114557. https://doi.org/10.1016/j.bcp.2021.114557 Cite
