Home Newsletters Mesenchymal Cell News HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

0
The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR).
[Advanced Healthcare Materials]
6807162 {6807162:2XQ96DYG} apa 50 1 161343 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-e28f787747249c33b695d6db70ae6189%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%222XQ96DYG%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Born%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBorn%2C%20L.%20J.%2C%20Chang%2C%20K.-H.%2C%20Shoureshi%2C%20P.%2C%20Lay%2C%20F.%2C%20Bengali%2C%20S.%2C%20Hsu%2C%20A.%20T.%20W.%2C%20Abadchi%2C%20S.%20N.%2C%20Harmon%2C%20J.%20W.%2C%20%26amp%3B%20Jay%2C%20S.%20M.%20%28n.d.%29.%20HOTAIR-Loaded%20Mesenchymal%20Stem%5C%2FStromal%20Cell%20Extracellular%20Vesicles%20Enhance%20Angiogenesis%20and%20Wound%20Healing.%20%3Ci%3EAdvanced%20Healthcare%20Materials%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29%2C%202002070.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadhm.202002070%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadhm.202002070%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D2XQ96DYG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HOTAIR-Loaded%20Mesenchymal%20Stem%5C%2FStromal%20Cell%20Extracellular%20Vesicles%20Enhance%20Angiogenesis%20and%20Wound%20Healing%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%20J.%22%2C%22lastName%22%3A%22Born%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai-Hua%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pouria%22%2C%22lastName%22%3A%22Shoureshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Lay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sameer%22%2C%22lastName%22%3A%22Bengali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20Ting%20Wei%22%2C%22lastName%22%3A%22Hsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanaz%20Nourmohammadi%22%2C%22lastName%22%3A%22Abadchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20W.%22%2C%22lastName%22%3A%22Harmon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20M.%22%2C%22lastName%22%3A%22Jay%22%7D%5D%2C%22abstractNote%22%3A%22Chronic%20wounds%20remain%20a%20substantial%20source%20of%20morbidity%20worldwide.%20An%20emergent%20approach%20that%20may%20be%20well-suited%20to%20induce%20the%20complex%2C%20multicellular%20processes%20such%20as%20angiogenesis%20that%20are%20required%20for%20wound%20repair%20is%20the%20use%20of%20extracellular%20vesicles%20%28EVs%29.%20EVs%20contain%20a%20wide%20variety%20of%20proteins%20and%20nucleic%20acids%20that%20enable%20multifactorial%20signaling.%20Here%2C%20the%20capability%20of%20EVs%20is%20leveraged%20to%20be%20engineered%20via%20producer%20cell%20modification%20to%20investigate%20the%20therapeutic%20potential%20of%20EVs%20from%20mesenchymal%20stem%5C%2Fstromal%20cells%20%28MSCs%29%20transfected%20to%20overexpress%20long%20non-coding%20RNA%20HOX%20transcript%20antisense%20RNA%20%28HOTAIR%29.%20HOTAIR%20is%20previously%20shown%20by%20the%20authors%27%20group%20to%20be%20critical%20in%20mediating%20angiogenic%20effects%20of%20endothelial%20cell%20EVs%2C%20and%20MSCs%20are%20chosen%20as%20EV%20producer%20cells%20for%20this%20study%20due%20to%20their%20widely%20reported%20intrinsic%20angiogenic%20properties.%20The%20results%20indicate%20that%20MSCs%20overexpressing%20HOTAIR%20%28HOTAIR-MSCs%29%20produce%20EVs%20with%20increased%20HOTAIR%20content%20that%20promote%20angiogenesis%20and%20wound%20healing%20in%20diabetic%20%28db%5C%2Fdb%29%20mice.%20Further%2C%20endothelial%20cells%20exposed%20to%20HOTAIR-MSC%20EVs%20exhibit%20increased%20HOTAIR%20content%20correlated%20with%20upregulation%20of%20the%20angiogenic%20protein%20vascular%20endothelial%20growth%20factor.%20Thus%2C%20this%20study%20supports%20EV-mediated%20HOTAIR%20delivery%20as%20a%20strategy%20for%20further%20exploration%20toward%20healing%20of%20chronic%20wounds.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadhm.202002070%22%2C%22ISSN%22%3A%222192-2659%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpericles.pericles-prod.literatumonline.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fadhm.202002070%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-19T23%3A08%3A32Z%22%7D%7D%5D%7D
Born, L. J., Chang, K.-H., Shoureshi, P., Lay, F., Bengali, S., Hsu, A. T. W., Abadchi, S. N., Harmon, J. W., & Jay, S. M. (n.d.). HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing. Advanced Healthcare Materials, n/a(n/a), 2002070. https://doi.org/https://doi.org/10.1002/adhm.202002070 Cite
Abstract
Exit mobile version