Home Newsletters Neural Cell News Conserved Genetic Signatures Parcellate Cardinal Spinal Neuron Classes Into Local and Projection...

Conserved Genetic Signatures Parcellate Cardinal Spinal Neuron Classes Into Local and Projection Subsets

0
The authors reasoned that the expansion of new neuronal types occurred in a stepwise manner analogous to animal speciation, and they explored this by defining transcriptomic relationships using a top-down approach.
[Science]
6807162 {6807162:LZ7T7PDE} apa 50 1 161472 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-98d917a12eebad9ab1333d036b356424%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22LZ7T7PDE%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Osseward%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-23%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOsseward%2C%20P.%20J.%2C%20Amin%2C%20N.%20D.%2C%20Moore%2C%20J.%20D.%2C%20Temple%2C%20B.%20A.%2C%20Barriga%2C%20B.%20K.%2C%20Bachmann%2C%20L.%20C.%2C%20Beltran%2C%20F.%2C%20Gullo%2C%20M.%2C%20Clark%2C%20R.%20C.%2C%20Driscoll%2C%20S.%20P.%2C%20Pfaff%2C%20S.%20L.%2C%20%26amp%3B%20Hayashi%2C%20M.%20%282021%29.%20Conserved%20genetic%20signatures%20parcellate%20cardinal%20spinal%20neuron%20classes%20into%20local%20and%20projection%20subsets.%20%3Ci%3EScience%3C%5C%2Fi%3E%2C%20%3Ci%3E372%3C%5C%2Fi%3E%286540%29%2C%20385%26%23x2013%3B393.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscience.abe0690%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscience.abe0690%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DLZ7T7PDE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Conserved%20genetic%20signatures%20parcellate%20cardinal%20spinal%20neuron%20classes%20into%20local%20and%20projection%20subsets%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20J.%22%2C%22lastName%22%3A%22Osseward%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neal%20D.%22%2C%22lastName%22%3A%22Amin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20D.%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20A.%22%2C%22lastName%22%3A%22Temple%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%20K.%22%2C%22lastName%22%3A%22Barriga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%20C.%22%2C%22lastName%22%3A%22Bachmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Beltran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miriam%22%2C%22lastName%22%3A%22Gullo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20C.%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shawn%20P.%22%2C%22lastName%22%3A%22Driscoll%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20L.%22%2C%22lastName%22%3A%22Pfaff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marito%22%2C%22lastName%22%3A%22Hayashi%22%7D%5D%2C%22abstractNote%22%3A%22Neuronal%20identities%5CnNeurons%20of%20the%20mouse%20spinal%20cord%20can%20be%20identified%20by%20any%20of%20several%20metrics%2C%20including%20what%20neurotransmitters%20they%20use%2C%20what%20cells%20they%20connect%20to%2C%20where%20they%20are%20located%2C%20and%20what%20neuroprogenitor%20gave%20rise%20to%20them.%20Osseward%20et%20al.%20generated%20a%20different%20metric%2C%20genetic%20signatures%2C%20and%20identified%20classes%20of%20local%20and%20projection%20neurons%20that%20were%20otherwise%20heterogeneous%20by%20other%20classification%20systems.%20With%20this%20focus%20on%20a%20cell%27s%20genetic%20signature%2C%20its%20neurotransmitter%20phenotype%2C%20which%20is%20accessible%20by%20a%20variety%20of%20transcriptional%20routes%2C%20can%20be%20seen%20as%20a%20parallel%20to%20convergent%20evolution%20in%20development.%5CnScience%2C%20this%20issue%20p.%20385%5CnMotor%20and%20sensory%20functions%20of%20the%20spinal%20cord%20are%20mediated%20by%20populations%20of%20cardinal%20neurons%20arising%20from%20separate%20progenitor%20lineages.%20However%2C%20each%20cardinal%20class%20is%20composed%20of%20multiple%20neuronal%20types%20with%20distinct%20molecular%2C%20anatomical%2C%20and%20physiological%20features%2C%20and%20there%20is%20not%20a%20unifying%20logic%20that%20systematically%20accounts%20for%20this%20diversity.%20We%20reasoned%20that%20the%20expansion%20of%20new%20neuronal%20types%20occurred%20in%20a%20stepwise%20manner%20analogous%20to%20animal%20speciation%2C%20and%20we%20explored%20this%20by%20defining%20transcriptomic%20relationships%20using%20a%20top-down%20approach.%20We%20uncovered%20orderly%20genetic%20tiers%20that%20sequentially%20divide%20groups%20of%20neurons%20by%20their%20motor-sensory%2C%20local-long%20range%2C%20and%20excitatory-inhibitory%20features.%20The%20genetic%20signatures%20defining%20neuronal%20projections%20were%20tied%20to%20neuronal%20birth%20date%20and%20conserved%20across%20cardinal%20classes.%20Thus%2C%20the%20intersection%20of%20cardinal%20class%20with%20projection%20markers%20provides%20a%20unifying%20taxonomic%20solution%20for%20systematically%20identifying%20distinct%20functional%20subsets.%5CnFunctionally%20discrete%20populations%20among%20spinal%20cord%20neurons%20are%20grouped%20according%20to%20genetic%20signatures%20rather%20than%20neurotransmitter%20identity.%5CnFunctionally%20discrete%20populations%20among%20spinal%20cord%20neurons%20are%20grouped%20according%20to%20genetic%20signatures%20rather%20than%20neurotransmitter%20identity.%22%2C%22date%22%3A%222021%5C%2F04%5C%2F23%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscience.abe0690%22%2C%22ISSN%22%3A%220036-8075%2C%201095-9203%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fscience.sciencemag.org%5C%2Fcontent%5C%2F372%5C%2F6540%5C%2F385%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-22T21%3A58%3A44Z%22%7D%7D%5D%7D
Osseward, P. J., Amin, N. D., Moore, J. D., Temple, B. A., Barriga, B. K., Bachmann, L. C., Beltran, F., Gullo, M., Clark, R. C., Driscoll, S. P., Pfaff, S. L., & Hayashi, M. (2021). Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets. Science, 372(6540), 385–393. https://doi.org/10.1126/science.abe0690 Cite
AbstractPress Release
Exit mobile version