Scientists investigate the role of chaperone-mediated autophagy, a selective autophagy shown to degrade neurodegeneration-related proteins, in neuronal proteostasis.
[Cell]
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Bourdenx, M., Martín-Segura, A., Scrivo, A., Rodriguez-Navarro, J. A., Kaushik, S., Tasset, I., Diaz, A., Storm, N. J., Xin, Q., Juste, Y. R., Stevenson, E., Luengo, E., Clement, C. C., Choi, S. J., Krogan, N. J., Mosharov, E. V., Santambrogio, L., Grueninger, F., Collin, L., … Cuervo, A. M. (2021). Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.03.048 Cite
