Using direct conversion of Alzheimer’s disease patient fibroblasts into induced neurons, scientists generated an age-equivalent neuronal model.
[Cell Stem Cell]
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Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., Agarwal, R. K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A. C. M., Glass, C. K., … Gage, F. H. (2021). Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.04.004 Cite
