Researchers showed that in mouse hippocampal neurons, dense core vesicles fusion was strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.
[Proceedings of the National Academy of Sciences of the United States of America]
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Westen, R. van, Poppinga, J., Arazola, R. D., Toonen, R. F., & Verhage, M. (2021). Neuromodulator release in neurons requires two functionally redundant calcium sensors. Proceedings of the National Academy of Sciences, 118(18). https://doi.org/10.1073/pnas.2012137118 Cite
