Using patient-derived iPSC neurons expressing a tau aggregation biosensor, researchers developed a cell culture system that allowed continuous assessment of both induced tau aggregation and neuronal viability at single-cell resolution for periods of >1 week.
[Journal of Neuroscience]
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Oakley, D. H., Klickstein, N., Commins, C., Chung, M., Dujardin, S., Bennett, R. E., Hyman, B. T., & Frosch, M. P. (2021). Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. Journal of Neuroscience. https://doi.org/10.1523/JNEUROSCI.2590-20.2021 Cite
