Investigators analyzed Lgr5-Cre; APCmin; HER2V777LTg mice by morphologic and gene expression assays on intestinal sections and organoids derived from the epithelium.
[Cellular and Molecular Gastroenterology and Hepatology]
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Murray, E., Cheng, X., Krishna, A., Jin, X., Ohara, T. E., Stappenbeck, T. S., & Bose, R. (2021). HER2 and APC mutations promote altered crypt-villus morphology and marked hyperplasia in the intestinal epithelium. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2021.04.012 Cite
