In vitro, TGF-β1 treatment augmented glycogen synthase kinase 3β expression in tubular epithelial cells, concomitant with dedifferentiation, cell cycle arrest at G2/M phase, excessive accumulation of extracellular matrix, and overproduction of profibrotic cytokines like PAI-1 and CTGF.
[Cell Death & Disease]
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Chen, B., Wang, P., Liang, X., Jiang, C., Ge, Y., Dworkin, L. D., & Gong, R. (2021). Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03709-5 Cite
