Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis.
[Molecular Cell]
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Pan, Q., Zhong, S., Wang, H., Wang, X., Li, N., Li, Y., Zhang, G., Yuan, H., Lian, Y., Chen, Q., Han, Y., Guo, J., Liu, Q., Qiu, T., Jiang, J., Li, Q., Tan, M., Yin, H., Peng, J., … Qin, J. (2021). The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2021.04.009 Cite
