Scientists provide genetic evidence that mTOR activation promotes proliferation and inhibits differentiation of Lgr5+ gastric epithelial progenitors in gastric homeostasis and tumorigenesis.
[Cell Reports]
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Li, K., Wu, H., Wang, A., Charron, J., Mishina, Y., Habib, S. L., Liu, H., & Li, B. (2021). mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways. Cell Reports, 35(5). https://doi.org/10.1016/j.celrep.2021.109069 Cite
