Using the Drosophila midgut as a model, researchers have recently described that adult intestinal stem cells, do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia.
[Biology Open]
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Brás, R., Monteiro, A., Sunkel, C. E., & Resende, L. P. (2021). Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut. Biology Open, bio.058623. https://doi.org/10.1242/bio.058623 Cite
