Scientists identified functional network parameters that are most reliably affected by GABAergic modulation as such, and through alterations of excitation/inhibition balance by reduced expression of Cadherin – 13 in GABAergic neurons.
[Molecular Psychiatry]
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Mossink, B., van Rhijn, J.-R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E. M., van Hugte, E. J. H., Bak, J., Verboven, A. H. A., Selten, M., Negwer, M., Latour, B. L., van der Werf, I., Keller, J. M., Klein Gunnewiek, T. M., Schoenmaker, C., Oudakker, A., Anania, A., Jansen, S., … Nadif Kasri, N. (2021). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 1–18. https://doi.org/10.1038/s41380-021-01117-x Cite
