Using molecular and electrophysiological techniques, researchers found that leptin increased the surface localization of GABAA receptors and the number of functional GABAergic synapses in hippocampal cultures from male and female rat pups.
[Science Signaling]
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Sahin, G. S., Rodriguez-Llamas, J. L., Dillon, C., Medina, I., Appleyard, S. M., Gaiarsa, J.-L., & Wayman, G. A. (2021). Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons. Science Signaling, 14(683). https://doi.org/10.1126/scisignal.abe4111 Cite
