Investigators demonstrated that Arrb2 interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL.
[Cell Death & Disease]
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Bae, W.-Y., Choi, J.-S., Nam, S., & Jeong, J.-W. (2021). β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. Cell Death & Differentiation, 1–13. https://doi.org/10.1038/s41418-021-00802-2 Cite
