Epithelial-Mesenchymal Transition Sensitizes Breast Cancer Cells to Cell Death via the Fungus-Derived Sesterterpenoid Ophiobolin A

Using a model of experimentally induced epithelial-mesenchymal transition (EMT) in human mammary epithelial cells, researchers demonstrated that breast cancer cells enriched for EMT features were more sensitive to cytotoxicity induced by ophiobolin A.