Researchers identified an endocrine pathway regulated by Uncoupling protein 1 (UCP1) that antagonizes liver inflammation and pathology, independent of effects on obesity.
[Nature Metabolism]
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Mills, E. L., Harmon, C., Jedrychowski, M. P., Xiao, H., Garrity, R., Tran, N. V., Bradshaw, G. A., Fu, A., Szpyt, J., Reddy, A., Prendeville, H., Danial, N. N., Gygi, S. P., Lynch, L., & Chouchani, E. T. (2021). UCP1 governs liver extracellular succinate and inflammatory pathogenesis. Nature Metabolism, 1–14. https://doi.org/10.1038/s42255-021-00389-5 Cite
