Scientists found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice.
[Nature Communications]
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Georgiadi, A., Lopez-Salazar, V., Merahbi, R. E.-, Karikari, R. A., Ma, X., Mourão, A., Klepac, K., Bühler, L., Alfaro, A. J., Kaczmarek, I., Linford, A., Bosma, M., Shilkova, O., Ritvos, O., Nakamura, N., Hirose, S., Lassi, M., Teperino, R., Machado, J., … Herzig, S. (2021). Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nature Communications, 12(1), 2999. https://doi.org/10.1038/s41467-021-22579-1 Cite
