By ATAC-seq analyses of EpCAM+ pancreatic ductal adenocarcinoma malignant epithelial cells sorted from 54 freshly resected human tumors, we show here the discovery of a signature of 1092 chromatin loci displaying differential accessibility between patients with disease free survival (DFS) 1 year.
[Nature Communications]
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Dhara, S., Chhangawala, S., Chintalapudi, H., Askan, G., Aveson, V., Massa, A. L., Zhang, L., Torres, D., Makohon-Moore, A. P., Lecomte, N., Melchor, J. P., Bermeo, J., Cardenas, A., Sinha, S., Glassman, D., Nicolle, R., Moffitt, R., Yu, K. H., Leppanen, S., … Leach, S. D. (2021). Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility. Nature Communications, 12(1), 3044. https://doi.org/10.1038/s41467-021-23237-2 Cite
