Scientists established liver fibrosis models using multicellular tumor spheroids (MCTSs) composed of hepatocellular carcinoma (HCC) and stromal cells such as fibroblasts (WI38), hepatic stellate cells (LX2), and endothelial cells (HUVEC) seeded at constant ratios.
[Scientific Reports]
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Song, Y., Kim, S., Heo, J., Shum, D., Lee, S.-Y., Lee, M., Kim, A.-R., & Seo, H. R. (2021). Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model. Scientific Reports, 11(1), 10931. https://doi.org/10.1038/s41598-021-90263-x Cite
