Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
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In vitro assessment of a synergistic combination of Gemcitabine and Zebularine in pancreatic cancer cells. (2021). Experimental Cell Research, 112660. https://doi.org/10.1016/j.yexcr.2021.112660 Cite
