Researchers showed that active mechanical forces increase growth and lead to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells (hPSC).
[Nature Communications]
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Abdel Fattah, A. R., Daza, B., Rustandi, G., Berrocal-Rubio, M. Á., Gorissen, B., Poovathingal, S., Davie, K., Barrasa-Fano, J., Cóndor, M., Cao, X., Rosenzweig, D. H., Lei, Y., Finnell, R., Verfaillie, C., Sampaolesi, M., Dedecker, P., Van Oosterwyck, H., Aerts, S., & Ranga, A. (2021). Actuation enhances patterning in human neural tube organoids. Nature Communications, 12(1), 3192. https://doi.org/10.1038/s41467-021-22952-0 Cite
