The proteomics studies on liver co-cultures implicated the activated hepatic stellate cells-secreted chemokine CXCL12 in the induction of NK cell quiescence through its cognate receptor CXCR4.
[Nature]
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Correia, A. L., Guimaraes, J. C., Auf der Maur, P., De Silva, D., Trefny, M. P., Okamoto, R., Bruno, S., Schmidt, A., Mertz, K., Volkmann, K., Terracciano, L., Zippelius, A., Vetter, M., Kurzeder, C., Weber, W. P., & Bentires-Alj, M. (2021). Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy. Nature, 1–6. https://doi.org/10.1038/s41586-021-03614-z Cite
