Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.
[Journal of Clinical Investigation]
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Kim, C., Jin, J., Ye, Z., Jadhav, R. R., Gustafson, C. E., Hu, B., Cao, W., Tian, L., Weyand, C. M., & Goronzy, J. J. (2021). Histone deficiency and accelerated replication stress in T cell aging. The Journal of Clinical Investigation, 131(11). https://doi.org/10.1172/JCI143632 Cite
