In situ hybridization, immunolabelling, cell tracking and transcriptomic analyses show that these embryoids form the three germ layers through a gastrulation process and that they exhibit a wide range of developmental structures, highly similar to neurula-stage mouse embryos.
[Nature Communications]
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Xu, P.-F., Borges, R. M., Fillatre, J., de Oliveira-Melo, M., Cheng, T., Thisse, B., & Thisse, C. (2021). Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nature Communications, 12(1), 3277. https://doi.org/10.1038/s41467-021-23653-4 Cite
