Investigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.
[Scientific Reports]
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Zbodakova, O., Chalupsky, K., Sarnova, L., Kasparek, P., Jirouskova, M., Gregor, M., & Sedlacek, R. (2021). ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Scientific Reports, 11(1), 11414. https://doi.org/10.1038/s41598-021-90716-3 Cite
