Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).
[Scientific Reports]
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Chen, J., Debebe, A., Zeng, N., Kopp, J., He, L., Sander, M., & Stiles, B. L. (2021). Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Scientific Reports, 11(1), 11823. https://doi.org/10.1038/s41598-021-90958-1 Cite
