Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
[Cancer Cell]
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Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Castro, L. N. G., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., … Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.002 Cite
