Investigators examined whether mineralocorticoid receptor antagonists can ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.
[Scientific Reports]
7753456
{7753456:2KF284DV}
apa
50
1
163112
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-95f9cbe69c370ebd560b9b2c1da89891%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%222KF284DV%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lee%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELee%2C%20H.%2C%20Choi%2C%20E.-J.%2C%20Kim%2C%20E.%20J.%2C%20Son%2C%20E.%20D.%2C%20Kim%2C%20H.-J.%2C%20Park%2C%20W.-S.%2C%20Kang%2C%20Y.-G.%2C%20Shin%2C%20K.-O.%2C%20Park%2C%20K.%2C%20Kim%2C%20J.-C.%2C%20Kim%2C%20S.-N.%2C%20%26amp%3B%20Choi%2C%20E.%20H.%20%282021%29.%20A%20novel%20mineralocorticoid%20receptor%20antagonist%2C%207%2C3%26%23x2019%3B%2C4%26%23x2019%3B-trihydroxyisoflavone%20improves%20skin%20barrier%20function%20impaired%20by%20endogenous%20or%20exogenous%20glucocorticoids.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2011920.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-91450-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-91450-6%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D2KF284DV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20novel%20mineralocorticoid%20receptor%20antagonist%2C%207%2C3%27%2C4%27-trihydroxyisoflavone%20improves%20skin%20barrier%20function%20impaired%20by%20endogenous%20or%20exogenous%20glucocorticoids%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanil%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eun-Jeong%22%2C%22lastName%22%3A%22Choi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eun%20Jung%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eui%20Dong%22%2C%22lastName%22%3A%22Son%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hyoung-June%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Won-Seok%22%2C%22lastName%22%3A%22Park%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Young-Gyu%22%2C%22lastName%22%3A%22Kang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyong-Oh%22%2C%22lastName%22%3A%22Shin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungho%22%2C%22lastName%22%3A%22Park%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jin-Chul%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Su-Nam%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eung%20Ho%22%2C%22lastName%22%3A%22Choi%22%7D%5D%2C%22abstractNote%22%3A%22Excess%20glucocorticoids%20%28GCs%29%20with%20either%20endogenous%20or%20exogenous%20origins%20deteriorate%20skin%20barrier%20function.%20GCs%20bind%20to%20mineralocorticoid%20and%20GC%20receptors%20%28MRs%20and%20GRs%29%20in%20normal%20human%20epidermal%20keratinocytes%20%28NHEKs%29.%20Inappropriate%20MR%20activation%20by%20GCs%20mediates%20various%20GC-induced%20cutaneous%20adverse%20events.%20We%20examined%20whether%20MR%20antagonists%20can%20ameliorate%20GC-mediated%20skin%20barrier%20dysfunction%20in%20NHEKs%2C%20reconstructed%20human%20epidermis%20%28RHE%29%2C%20and%20subjects%20under%20psychological%20stress%20%28PS%29.%20In%20a%20preliminary%20clinical%20investigation%2C%20topical%20MR%20antagonists%20improved%20skin%20barrier%20function%20in%20topical%20GC-treated%20subjects.%20In%20NHEKs%2C%20cortisol%20induced%20nuclear%20translocation%20of%20GR%20and%20MR%2C%20and%20GR%20and%20MR%20antagonists%20inhibited%20cortisol-induced%20reductions%20of%20keratinocyte%20differentiation.%20We%20identified%207%2C3%5Cu2019%2C4%5Cu2019-trihydroxyisoflavone%20%287%2C3%5Cu2019%2C4%5Cu2019-THIF%29%20as%20a%20novel%20compound%20that%20inhibits%20MR%20transcriptional%20activity%20by%20screening%2030%20cosmetic%20compounds.%207%2C3%5Cu2019%2C4%5Cu2019-THIF%20ameliorated%20the%20cortisol%20effect%20which%20decreases%20keratinocyte%20differentiation%20in%20NHEKs%20and%20RHE.%20In%20a%20clinical%20study%20on%20PS%20subjects%2C%207%2C3%27%2C4%27-THIF%20%280.1%25%29-containing%20cream%20improved%20skin%20barrier%20function%2C%20including%20skin%20surface%20pH%2C%20barrier%20recovery%20rate%2C%20and%20stratum%20corneum%20lipids.%20In%20conclusion%2C%20skin%20barrier%20dysfunction%20owing%20to%20excess%20GC%20is%20mediated%20by%20MR%20and%20GR%3B%20thus%2C%20it%20could%20be%20prevented%20by%20treatment%20with%20MR%20antagonists.%20Therefore%2C%20topical%20MR%20antagonists%20are%20a%20promising%20therapeutic%20option%20for%20skin%20barrier%20dysfunction%20after%20topical%20GC%20treatment%20or%20PS.%22%2C%22date%22%3A%222021-06-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-91450-6%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-91450-6%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22DUPVZUHA%22%5D%2C%22dateModified%22%3A%222021-06-07T16%3A45%3A32Z%22%7D%7D%5D%7D
Lee, H., Choi, E.-J., Kim, E. J., Son, E. D., Kim, H.-J., Park, W.-S., Kang, Y.-G., Shin, K.-O., Park, K., Kim, J.-C., Kim, S.-N., & Choi, E. H. (2021). A novel mineralocorticoid receptor antagonist, 7,3’,4’-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids. Scientific Reports, 11(1), 11920. https://doi.org/10.1038/s41598-021-91450-6 Cite
