The authors identified a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid was the most abundant fatty acid in the filtrate from Pluronic F68 fermentation of Cutibacterium acnes and reduced the DOPA-positive melanocytes by significantly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2.
[Scientific Reports]
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Kao, H.-J., Wang, Y.-H., Keshari, S., Yang, J. J., Simbolon, S., Chen, C.-C., & Huang, C.-M. (2021). Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis. Scientific Reports, 11(1), 11980. https://doi.org/10.1038/s41598-021-91386-x Cite
