Investigators described the creation of a heterodimeric bifunctional fusion molecule, HCW9218, constructed using their soluble tissue factor-based scaffold technology. This complex comprised extracellular domains of the human transforming growth factor-β receptor II and a human interleukin (IL)-15/IL-15 receptor α complex.
[Molecular Therapy]
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Liu, B., Zhu, X., Kong, L., Wang, M., Spanoudis, C., Chaturvedi, P., George, V., Jiao, J., You, L., Egan, J. O., Echeverri, C., Gallo, V. L., Xing, J., Ravelo, K., Prendes, C., Antolinez, J., Denissova, J., Muniz, G. J., Jeng, E. K., … Wong, H. C. (2021). Bifunctional TGF-β trap/IL-15 Protein Complex Elicits Potent NK Cell and CD8+ T Cell Immunity Against Solid Tumors. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.001 Cite
