Investigators showed a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.
[Nature Communications]
6445218
{6445218:D4TTMXT3}
apa
50
1
163188
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d9e4f560804354403a8886fd885ec39a%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22D4TTMXT3%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Callender%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECallender%2C%20L.%20A.%2C%20Schroth%2C%20J.%2C%20Carroll%2C%20E.%20C.%2C%20Garrod-Ketchley%2C%20C.%2C%20Romano%2C%20L.%20E.%20L.%2C%20Hendy%2C%20E.%2C%20Kelly%2C%20A.%2C%20Lavender%2C%20P.%2C%20Akbar%2C%20A.%20N.%2C%20Chapple%2C%20J.%20P.%2C%20%26amp%3B%20Henson%2C%20S.%20M.%20%282021%29.%20GATA3%20induces%20mitochondrial%20biogenesis%20in%20primary%20human%20CD4%2B%20T%20cells%20during%20DNA%20damage.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%203379.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-23715-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-23715-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DD4TTMXT3%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22GATA3%20induces%20mitochondrial%20biogenesis%20in%20primary%20human%20CD4%2B%20T%20cells%20during%20DNA%20damage%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%20A.%22%2C%22lastName%22%3A%22Callender%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Schroth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20C.%22%2C%22lastName%22%3A%22Carroll%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Conor%22%2C%22lastName%22%3A%22Garrod-Ketchley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%20E.%20L.%22%2C%22lastName%22%3A%22Romano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleanor%22%2C%22lastName%22%3A%22Hendy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Kelly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Lavender%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arne%20N.%22%2C%22lastName%22%3A%22Akbar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Paul%22%2C%22lastName%22%3A%22Chapple%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sian%20M.%22%2C%22lastName%22%3A%22Henson%22%7D%5D%2C%22abstractNote%22%3A%22GATA3%20is%20as%20a%20lineage-specific%20transcription%20factor%20that%20drives%20the%20differentiation%20of%20CD4%2B%20T%20helper%202%20%28Th2%29%20cells%2C%20but%20is%20also%20involved%20in%20a%20variety%20of%20processes%20such%20as%20immune%20regulation%2C%20proliferation%20and%20maintenance%20in%20other%20T%20cell%20and%20non-T%20cell%20lineages.%20Here%20we%20show%20a%20mechanism%20utilised%20by%20CD4%2B%20T%20cells%20to%20increase%20mitochondrial%20mass%20in%20response%20to%20DNA%20damage%20through%20the%20actions%20of%20GATA3%20and%20AMPK.%20Activated%20AMPK%20increases%20expression%20of%20PPARG%20coactivator%201%20alpha%20%28PPARGC1A%20or%20PGC1%5Cu03b1%20protein%29%20at%20the%20level%20of%20transcription%20and%20GATA3%20at%20the%20level%20of%20translation%2C%20while%20DNA%20damage%20enhances%20expression%20of%20nuclear%20factor%20erythroid%202-related%20factor%202%20%28NFE2L2%20or%20NRF2%29.%20PGC1%5Cu03b1%2C%20GATA3%20and%20NRF2%20complex%20together%20with%20the%20ATR%20to%20promote%20mitochondrial%20biogenesis.%20These%20findings%20extend%20the%20pleotropic%20interactions%20of%20GATA3%20and%20highlight%20the%20potential%20for%20GATA3-targeted%20cell%20manipulation%20for%20intervention%20in%20CD4%2B%20T%20cell%20viability%20and%20function%20after%20DNA%20damage.%22%2C%22date%22%3A%222021-06-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-021-23715-7%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-021-23715-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-08T05%3A44%3A19Z%22%7D%7D%5D%7D
Callender, L. A., Schroth, J., Carroll, E. C., Garrod-Ketchley, C., Romano, L. E. L., Hendy, E., Kelly, A., Lavender, P., Akbar, A. N., Chapple, J. P., & Henson, S. M. (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. Nature Communications, 12(1), 3379. https://doi.org/10.1038/s41467-021-23715-7 Cite
