Scientists demonstrated that hPDLSCs, hBMSCs and hDPSCs could directly differentiate into neuron-like cells without passing through a mitotic stage and that they shrunk dramatically and changed their morphology to that of neuron-like cells through active neurite extension.
[Scientific Reports]
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Bueno, C., Martínez-Morga, M., García-Bernal, D., Moraleda, J. M., & Martínez, S. (2021). Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes. Scientific Reports, 11(1), 12034. https://doi.org/10.1038/s41598-021-91566-9 Cite
