Home Newsletters Pulmonary Cell News Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

Inhibition of miR-1298-5p Attenuates Sepsis Lung Injury by Targeting SOCS6

0
miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.
[Molecular and Cellular Biochemistry]
7753456 {7753456:725NBQHZ} apa 50 1 163279 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-f68140a6104305014ddb1ff164debb74%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22725NBQHZ%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ma%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMa%2C%20J.%2C%20Xu%2C%20L.-Y.%2C%20Sun%2C%20Q.-H.%2C%20Wan%2C%20X.-Y.%2C%20%26amp%3B%20BingLi.%20%282021%29.%20Inhibition%20of%20miR-1298-5p%20attenuates%20sepsis%20lung%20injury%20by%20targeting%20SOCS6.%20%3Ci%3EMolecular%20and%20Cellular%20Biochemistry%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D725NBQHZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Inhibition%20of%20miR-1298-5p%20attenuates%20sepsis%20lung%20injury%20by%20targeting%20SOCS6%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jian%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Li-Yun%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiu-Hong%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-Yu%22%2C%22lastName%22%3A%22Wan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22BingLi%22%7D%5D%2C%22abstractNote%22%3A%22Sepsis%20is%20one%20of%20the%20leading%20causes%20of%20morbidity%20and%20mortality%20and%20a%20major%20cause%20of%20acute%20lung%20injury%20%28ALI%29.%20carried%20by%20exosomes%20play%20a%20role%20in%20a%20variety%20of%20diseases.%20However%2Cthere%20are%20not%20many%20studies%20of%20exosomal%20miRNAs%20in%20sepsis%20and%20sepsis%20lung%20injury.miR-1298-5p%20and%20suppressor%20of%20cytokine%20signaling%206%20%28SOCS6%29%20were%20silenced%20or%20overexpressed%20in%20human%20bronchial%20epithelial%20cells%20%28BEAS-2B%29.%20PKH-67%20Dye%20was%20used%20to%20trace%20exosome%20endocytosis.%20Cell%20permeability%20was%20evaluated%20by%20measuring%20trans-epithelial%20electrical%20resistance%20%28TEER%29%20and%20FITC%20dextran%20flux.%20ELISA%20kits%20were%20used%20for%20cytokine%20detection.%20Quantitative%20RT-PCR%20and%20western%20blots%20were%20used%20to%20evaluate%20gene%20expression.%20miR-1298-5p%20was%20elevated%20in%20exosomes%20from%20patients%20with%20sepsis%20lung%20injury%20%28Sepsis_exo%29.%20Treatment%20of%20BEAS-2B%20cells%20using%20Sepsis_exo%20significantly%20inhibited%20cell%20proliferation%2C%20and%20induced%20cell%20permeability%20and%20inflammatory%20response.%20miR-1298-5p%20directly%20targeted%20SOCS6.%20Overexpressing%20SOCS6%20reversed%20miR-1298-5p-induced%20cell%20permeability%20and%20inflammatory%20response.%20Inhibition%20of%20STAT3%20blocked%20SOCS6-silencing%20caused%20significant%20increase%20of%20cell%20permeability%20and%20inflammation.%20Exosomes%20isolated%20from%20patients%20of%20sepsis%20lung%20injury%20increased%20cell%20permeability%20and%20inflammatory%20response%20in%20BEAS-2B%20cells%20through%20exosomal%20miR-1298-5p%20which%20targeted%20SOCS6%20via%20STAT3%20pathway.%20The%20findings%20highlight%20the%20importance%20of%20miR-1298-5p%5C%2FSOCS6%5C%2FSTAT3%20axis%20in%20sepsis%20lung%20injury%20and%20provide%20new%20insights%20into%20therapeutic%20strategies%20for%20sepsis%20lung%20injury.%22%2C%22date%22%3A%222021-06-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11010-021-04170-w%22%2C%22ISSN%22%3A%221573-4919%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11010-021-04170-w%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-10T19%3A14%3A20Z%22%7D%7D%5D%7D
Ma, J., Xu, L.-Y., Sun, Q.-H., Wan, X.-Y., & BingLi. (2021). Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04170-w Cite
Abstract
Exit mobile version