Overexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells are less tumorigenic in the brain than in control cells.
[Cell Death & Disease]
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Liu, H., Xing, R., Ou, Z., Zhao, J., Hong, G., Zhao, T.-J., Han, Y., & Chen, Y. (2021). G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03897-0 Cite
