Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.
[Cell Death & Disease]
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Li, M., Sun, C., Bu, X., Que, Y., Zhang, L., Zhang, Y., Zhang, L., Lu, S., Huang, J., Zhu, J., Wang, J., Sun, F., & Zhang, Y. (2021). ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma. Cell Death & Disease, 12(6), 1–13. https://doi.org/10.1038/s41419-021-03894-3 Cite
