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HIF-1α Is a Negative Regulator of Interferon Regulatory Factors: Implications for Interferon Production by Hypoxic Monocytes

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To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.
[Proceedings of the National Academy of Sciences of the United States of America]
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Peng, T., Du, S.-Y., Son, M., & Diamond, B. (2021). HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes. Proceedings of the National Academy of Sciences, 118(26). https://doi.org/10.1073/pnas.2106017118 Cite
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